A Next Generation Multi-Particulate Delivery System
Sympfiny™ is an innovative system for dosing and dispensing multiparticulate, dry powder, and microsphere, drug formulations for oral delivery.
For more information on Sympfiny visit sympfiny.com
Intuitively Simple & Child Friendly
The breakthrough system designed by HSD Ventures™ enables caregivers to store, extract, and deliver dry drugs with the same familiar technique used with liquid oral drugs.
Designed with the entire supply chain in mind, the system fits common bottle sizes and can be pre-filled or filled at a pharmacy. The internal valve and bottle cap protects the drug through storage and use. The re-usable syringe comes in two sizes and has selectable dose settings.
- No inherent taste so it’s the ideal substrate for taste masking, increasing compliance and reducing possible rejection by child
- Allows multitude of dose flexibility
- Reduces and possibly eliminates need for preservatives, sweeteners, flavorants, dyes, etc.
- May be dosed with or without water
- The technology can be applied to the active ingredients of a wide range of drug molecules.
- Different drugs formulated as MP powders can be combined to form homogenous mixtures, allowing the administration of multiple drugs and potentially multiple different drug release profiles.
- MP powder flows similar to a liquid and ideally with a non-gritty mouth feel.
- MP powders are typically stable across all global zones and therefore do not require cold chain storage.
What are Multiparticulates?
In addition, multiparticulates provide predictable and consistent gastrointestinal transit and lower chances of undesirable events (e.g., dose dumping, colonic streaming) associated with tablets. These multiparticulates can be dosed within capsules, tablets (microspheres, coated beads) or sachets.
Download the Sympfiny™ Spec Sheet
Press Release: Institute for Pediatric Innovation and Pfizer collaborated on the open innovation pediatric device challenge.
IPI and Pfizer partnered in an open innovation challenge to solicit and support innovative ideas for a system consisting of a package and dispensing device that will be used to deliver oral solid MP-formulated medicines to children. A panel led by IPI composed of engineers, end users, and experts from the Gates Foundation, New England Pediatric Device Consortium, PATH, and Pfizer, reviewed submissions to decide which proposals would receive funding.
HSD’s novel design features a proprietary bottle for storage of the multiparticulates and a syringe for dosing. This novel system is designed to be used similar to existing liquid oral syringes and vials, minimizing the length of the learning curve. HSD has partnered with The Röchling Group; a global contract manufacturer specializing in the manufacture of drugs delivery devices, to fully develop the delivery system.